Marc Anderson

Marc Anderson

Associate Professor
At SF State since 2007
Phone: (415) 338-6495
Location: TH 636


B.S. (1995) University of Colorado at Boulder, Computer Science
Ph.D. (2001) University of California at Santa Cruz, Organic Chemistry

Research Areas: Organic and Medicinal Chemistry

Our group uses organic synthesis and computational chemistry as tools to design inhibitors of therapeutically relevant drug targets in human illness. Currently we are focused on various channel proteins as drug targets: TMEM16A, UT-A, CFTR, pendrin, etc.


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Braslau, R. B.; Anderson, M. O. (1998) "Abstraction of deuterium from dideuteroglycine by aryl radical: A model for 1,4-benzene diradical reactions with proteins." Tetrahedron Lett. 39, 4227-4230.

Braslau, R. B.; Anderson, M. O. (2001) "Nitroxide Radicals" (Review). In Renaud, P.; Sibi, M. (eds): Radicals In Organic Synthesis. Wiley-VCH, Weinheim, Germany, pp. 127-149.

Braslau, R. B.; Anderson, M. O.; Rivera, F.; Jimenez, A.; Haddad, T; Axon, J. R. (2002). "Acyl hydrazines as precursors to acyl radicals." Tetrahedron, 58, 5513-5523.

Anderson, M. O.; Moser, J.; Sherrill, J.; Guy, R. K. (2004), “A Convenient Procedure for Parallel Ester Hydrolysis." (PDF) Synlett, 13, 2391-2393.

Anderson, M. O.; Shellat, A. S.; Guy, R. K. (2005), "A novel solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin." Journal of Organic Chemistry, 70(12), 4578-4584.

Anderson, M. O.; Sherrill, J.; Liou, A. P.; Weisman, J. L.; DeRisi, J. L.; Guy, R. K. (2006). “Parallel synthesis of 9-aminoacridines and evaluation against chloroquine-resistant Plasmodium falciparum.” Bioorganic and Medicinal Chemistry, 14(2), 334-343.

Anderson, M. O.; Yu, H.; Penaranda, C.; Maddux, B. A.; Goldfine, I. D.; Youngren, J. F.; Guy, R. K. (2006) “Parallel synthesis of diarylureas and evaluation against insulin-like growth factor receptor (IGF-1R).” Journal of Combinatorial Chemistry, 8(5), 784-790.

May, B. C. H.; Witkop, J.; Sherrill, J.; Anderson, M.O.; Madrid, P. B.; Zorn, J. A.; Prusiner, S. B.; Cohen, F. E.; Guy, R. K. (2006) “Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.” Bioorganic and Medicinal Chemistry Letters, 16(18), 4913-4916.

Blecha J. E.; Anderson M. O.; Chow, J. M.; Guevarra, C. C.; Pender, C.; Penaranda, C.; Zavodovskaya, M., Youngren, J. F.; Berkman C. E. (2007) “Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs” Bioorganic and Medicinal Chemistry Letters, 17(14), 4026-4029.

Wu, L. Y.; Anderson, M. O.; Toriyabe, Y.; Maung, J.; Campbell, T. Y.; Tajon, C.; Kazak, M.; Moser, J. Berkman, C. E. (2007) “The Molecular Pruning of a Phosphoramidate Peptidomimetic Inhibitor of Prostate-Specific Membrane Antigen” Bioorganic and Medicinal Chemistry, 15(23), 7434-7443.

Anderson, M. O.; Wu, L. Y.; Santiago, N.; Moser, J.; Rowley, J. A.; Davis, E.; Berkman, C. B. (2007) “Substrate specificity of prostate-specific membrane antigen.” Bioorganic and Medicinal Chemistry, 15(21), 6678-6686.

Wu, L. Y.; Do, J.; Kazak, M.; Page, H.; Toriyabe, Y., Anderson, M. O., Berkman, C. E. (2007) “Phosphoramidate Derivatives Of Hydroxysteroids As Inhibitors Of Prostate-Specific Membrane Antigen” Bioorganic and Medicinal Chemistry Letters, 18(1), 281-284.

Li, F.; Pham, J. D.; Anderson, M. O.; Youngren, J. F. (2009) “Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling” European Journal of Pharmacology, 616(1-3), 31-37.

Engen, W.; O’Brien, T. E.; Kelly, B.; Do, J.; Rillera, L.; Stapleton, L.; Youngren, J. F.; Anderson, M.O. (2010) “Synthesis of Aryl-Heteroaryl Ureas (AHUs) Based on 4-Aminoquinoline and Their Evaluation Against the Insulin-Like Growth Factor Receptor (IGF-1R).” Bioorganic and Medicinal Chemistry, 18, 5995-6005.

Zhang, Y.; Anderson, M.O.; Weisman, J.L.; Lu, M.; Choy, C. J.; Boyd, V. A.; Price, J.; Sigal, M.; Clark, J.; Connelly, M.; Zhu, F.; Guigenmde, W. A.; Liou, A. P.; Webb, T. R.; DeRisi, J. L.; Guy, R. K. (2010) “Evaluation of Diarylureas for Activity Against Plasmodium falciparum.” (PDF) ACS Medicinal Chemistry Letters, 6-13.

Blank, B.; Alayoglu, P.; Engen, W.; Choi, J. K.; Berkman, C. E.; Anderson, M. O. (2011) “N-substituted Glutamyl Sulfonamides as Inhibitors of Glutamate Carboxypeptidase II (GCP2)” Chemical Biology and Drug Design. 77, 241-247.

Tradtrantip, L.; Zhang, H.; Anderson, M.O.; Saadoun, S.; Phuan, P. W.; Papadopoulos, M. C.; Bennett, J. L.; Verkman, A. S. (2012) “Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica” FASEB. 26(5), 2197-2208.

Yao, C.; Anderson, M. O.; Zhang, J.; Yang, B.; Phuan, P. W.; Verkman, A. S. (2012) “Triazolothienopyrimidine Inhibitors of Urea Transporter UT-B Reduce Urine Concentration” J. Am. Soc. Nephrol. 23(7), 1210-1220.

Anderson, M. O.; Zhang, J.; Liu, Y.; Yao, C.; Phuan, P. W.; Verkman, A. S. (2012) “Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B”. J. Med. Chem. 55(12), 5942-5950.

O’Donoghue, A.J.; Eroy-Reveles, A.; Knudsen, G.M.; Ingram, J.; Zhou, M.; Statnekov, J.B.; Greninger, A.L.; Hostetter, D.R.; Qu, G.; Maltby, D.A.; Anderson, M.O.; DeRisi, J.L.; McKerrow, J.H.; Burlingame, A.L.; Craik, C.S. (2012) “Global Identification of Peptidase Specificity By Multiplex Substrate Profiling.” Nature: Methods. 9(11), 1095-1100.

Phuan, P-W.; Anderson, M. O.; Tradtrantip, L.; Zhang, H.; Tan, J.; Lam, C.; Bennett, J. L.; Verkman, A. S. (2012) “A Small-molecule Screen Yields Idiotype-specific Blockers of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4” Journal of Biochemistry. 287(44), 36837-36844.

Verkman, A. S.; Snyder, D.; Tradtrantip, L.; Thiagarajah, J. R.; Anderson, M. O. (2013) “CFTR Inhibitors” Current Pharmaceutical Design. 19(19), 3529-41.

Liu, Y.*; Esteva-Font, C.; Yao, C.; Phuan, P.W.; Verkman, A. S.; Anderson, M. O. (2013) “1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): New analogs and binding model.” Bioorg Med. Chem. Lett. 23(11), 3338-3341.

Choy, C. J.; Fulton, M. D.; Davis, A. L.; Hopkins, M.; Choi, J. K. Anderson, M. O.; Berkman, C. E. (2013) “Rationally Designed Sulfamides As Glutamate Carboxypeptidase II (GCPII) Inhibitors” Chemical Biology and Drug Design. 82(5), 612-619.

Valentine, C. D.; Anderson, M. O.; Papa, F. R.; Haggie, P. M. (2013) “X-Box Binding Protein 1 (XBP1s) is a Critical Determinant of Pseudomonas Aeruginosa Homoserine Lactone-Mediated Apoptosis.” PLoS Pathogens. 9(8), e1003576. Doi: 10.1371/journal.ppat.1003576.

Font-Esteva, C.; Phuan, P.W., Anderson, M. O.; Verkman, A. S. (2013) “A Small Molecule Screen Identifies Selective Inhibitors of Urea Transporter UT-A.” Chemistry and Biology. 20(10), 1235-1244.

Eagon, S.; Anderson, M. O. (2014) “Microwave Assisted Synthesis of Tetrahydro-β-Carbolines and β-Carbolines." European Journal of Organic Chemistry. 1653-1666. DOI: 10.1002/ejoc.201301580. 1653-1666

Verkman, A. S.; Anderson, M. O.; Papadopoulos, M. C. (2014) “Aquaporins: Important but Elusive Drug Targets." Nature Review Drug Discovery. 13(4), 259-277. PMID: 24625825.

Font-Esteva, C.; Cil; O.; Phuan, P.W., Su, T.; Lee, S.; Anderson, M. O.; Verkman, A. S. (2014) “Diuresis and Reduced Urinary Osmolality in Rats Produced by Small Molecule UT-A Selective Urea Transport Inhibitors.” FASEB Journal. 28(9), 3878-3890. PMID: 24843071

Verkman AS, Esteva-Font C, Cil O, Anderson M.O., Li F, Li M, Lei T, Ren H, Yang B. (2014) “Small-molecule inhibitors of urea transporters.” Subcell Biochem. 73:165-77. doi: 10.1007/978-94-017-9343-8_11. Review. PMID: 25298345

Esteva-Font C, Anderson M.O., Verkman AS. (2015) “Urea transporter proteins as targets for small-molecule diuretics.” Nature Reviews Nephrology. 11(2):113-23. doi: 10.1038/nrneph.2014.219. Epub 2014 Dec 9. Review. PMID: 25488859.

Esteva-Font C, Phuan PW, Lee S, Su T, Anderson M.O., Verkman AS. (2015) “Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.” Biochim Biophys Acta. 1848(5):1075-80. doi: 10.1016/j.bbamem.2015.01.004. PMID: 25613743.

Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson M.O., Ertunc M, Verkman AS. (2015) “Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.” Kidney Int. Aug;88(2):311-20. doi: 10.1038/ki.2015.138. PMID: 25993324.

Kim Y, Anderson M.O., Park J, Lee MG, Namkung W, Verkman AS. (2015) “Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.” Mol Pharmacol. 88(4):689-96. doi: 10.1124/mol.115.098368. PMID: 26174774.

Lee S, Esteva-Font C, Phuan PW, Anderson M.O., Verkman AS. (2015) “Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors.” Medchemcomm. 6:1278-1284. PMID: 26191399.

Cil, O.; Font-Esteva, C.; Tas S. T.; Su, T.; Lee, S. ; Anderson, M. O. ;Ertunc, M. ; Verkman, A. S. (2015) “Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats." Kidney Intl. 88(2):311-320. PMID: 25993324.

Kim Y.; Anderson M.O.; Park J.; Lee M.G.; Namkung W; Verkman A.S. (2015) “Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.” Mol Pharmacol. 88(4):689-96. PMID: 26174774.

Piechowicz, K.A., Truong, E.C.; Javed, K.M.; Chaney, R.R.; Wu, J.Y.; Phuan, P.W.; Verkman, A.S.; Anderson, M.O. (2016) “Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1” J. Enz. Inh. Med. Chem. 31(6):1362-1368. PMID 26796863.

Font-Esteva, C.; Jin, V.-J. ; Phuan, P.W. ; Anderson, M.O.; Verkman, A.S. (2016). “Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1." Mol. Pharmacol. 89(6):686-93. PMID 26993802.

Bayih, A.G.; Folefoc, A.; Mohon, A.N.; Eagon, S.; Anderson, M.; Pillai, D.R. (2016). “In vitro and in vivo anti-malarial activity of novel harmine-analog heat shock protein 90 inhibitors: a possible partner for artemisinin” Malar. J. 15(1):579. PMCID PMC5131496.

Tradtrantip, L.; Jin, B-J.; Yao, X.; Anderson, M.O.; Verkman, A.S. (2017). “Aquaporin-Targeted Therapeutics: State-of-the-Field.” Adv. Exp. Med. Biol. 969:239-250. PMID 28258578.

Truong, E.C.; Phuan, P.W.; Reggie A.L.; Fererra, L.; Galietta L.J.V.; Levy, S.E.; Moises, A.C.; Cil, O.; Diez-Cecilia, E.; Lee, S.; Verkman A.S.; Anderson M.O. (2017). “Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A).” J. Med. Chem. 60, 4626-4635. PMID 28493701. PMCID PMC5516794.

Durham, S.D.; Sierra, B.; Gomez, M.J.; Tran, J.K.; Anderson, M.O.; Whittington-Davis, N.A.; Eagon, S. (2017) “Synthesis of β-carbolines via a silver-mediated oxidation of tetrahydro-β-carbolines.” Tet. Lett. 58(28):2747-2750.

Lee, S.; Cil, O.; Diez-Cecilia, E.; Anderson, M.O.; Verkman, A.S. (2018) “Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1” J. Med. Chem. 61(7):3209-3217.

Bowen, L. R.; Li, D. J.; Nola, D.T.; Anderson, M.O.; Heying, M.; Groves, A.T.; Eagon, S. (2019) “Identification of potential Zika virus NS2B-NS3 protease inhibitors via docking, molecular dynamics, and consensus scoring-based virtual screening” J Mol. Mod. 25:194. PMID: 31209577.

Cil, O.; Anderson, M.O.; Yen, R.; Kelleher, B;* Huynh, T.L.; Seo, Y.; Nilsen, S.; Turner, J.R.; Verkman, A.S. (2019) “Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A” FASEB Journal. fj201900858R. PMID: 31299174.

Grants and Awards

Agency and type of grant: NIH-R01 subcontract R01 DK101373
Period: 04/01/2014 to 03/31/2019
Title: Urea transport inhibitors as a new class of diuretics
Role on the project: Subcontractor


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