The Baird Lab

Manipulating proteases, so you don't have to.

Publications

Batt, A.R., St. Germain, C.P., Gokey, T., Guliaev, A.B., Baird, T. Jr., Engineering trypsin for inhibitor resistance. Protein Science (2015) DOI: 10.002/pro. 2732

Tansey, J.T., Baird, T. Jr., Cox, M. M., Fox, K.M., Knight, J., Sears, D., Bell, E. Foundational concepts and underlying theories for majors in Biochemistry and Molecular Biology Biochem. Mol. Biol. Educ. (2013) 41, 287-296

Baird, T. T., Jr., and Craik, C. S. Trypsin Handbook of Proteolytic Enzymes, 3rd ed. (2013) 2594-2600

Baird, T. T., Jr., Trypsin, Brenner's Encyclopedia of Genetics, 2nd edition (2013) pp. 216-219

Gokey, T., Baird, T.T., Jr., and Guliaev, A.B. Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants J. Mol. Model (2012) 18, 4941-4954

Baird, T.T., Jr., Wright, W. D., and Craik, C. S. Conversion of Trypsin to a Functional Threonine Protease, Prot. Sci., (2006) 15, 1229-1238.

Halfon, S., Baird, T.T., Jr., and Craik, C. S. Trypsin Handbook of Proteolytic Enzymes, 2nd ed. (2004) 1483-1488

Baird, T.T., Jr. and Craik, C. S. Trypsin. Encyclopedia of Genetics, Academic Press, London (2001) 2071-2075.

Baird, T. T., Jr., Wang, B., Lodder, M., Hecht, S. M., and Craik, C. S. Generation of Active Trypsin with Chemical Cleavage, Tetrahedron Letters (2000) 56(48), 9477-9485

Wang, B., Lodder, M., Baird, T. T., Jr., Brown, K. C., Craik, C. S., and Hecht, S. M. Chemically Mediated Site-Specific Cleavage of Proteins, J. Am. Chem. Soc. (2000) 122, 7402-7403

Doyon, J. B., Hansen, E. A. M., Kim, C.-Y., Chang, J. S., Christianson, D. W., Madder, R. D., Voet, J. G., Baird,T. T., Jr., Fierke, C. A. and Jain, A. Linear Free Energy Relationships Implicate Three Modes of Binding for Fluoroaromatic Inhibitors to a Mutant of Carbonic Anhydrase II, Organic Lett. (2000) 2, 1189-1192.

Alber, B. E., Colangelo, C. M., Dong, J., Stålhabdske, C. M. V., Baird, T. T., Tu, C., Fierke, C. A., Silverman, D. N., Scott, R. A. and Ferry, J. G. Kinetic and Spectroscopic Characterization of the Gamma Carbonic Anhydrase from the Methanoarchaeon Methanosarcina thermophila, Biochemistry (1999) 38, pp. 13119-28

Baird, T. T., Jr., Waheed, A., Sly, W. S., and Fierke, C. A. Catalysis and Inhibition of Human Carbonic Anhydrase IV, Biochemistry, (1997) 36 pp. 2669-2678

Ippolito, J.A., Baird, T.T., Jr., McGee, S. A., Christianson, D. W., and Fierke, C. A. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity, Proc. Natl. Acad. Sci. USA, (1995), 92 pp. 5017-5021.

Wild, C., Dubay, J. W., Greenwell, T., Baird, T., Jr., Oas, T. G., McDanal, C., Hunter, E., and Matthews, T. Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex. Proc. Natl. Acad. Sci. USA, (1994), 91 pp. 12676-12680

Miller, T. M., Kwock, E. W., Baird, T. Jr., and Hale, A. Properties and Photodefinition of Poly(aromatic diacetylenes). MATERIALS, (1994) 6 pp. 1569-1574

Kwock, E. W., Baird, T., Jr., and Miller, T. M. Synthesis and Characterization of Soluble, High Molecular Weight Poly(aromatic diacetylenes), Macromolecules, (1993), 26 pp. 2935-2940